This web page was produced as an assignment for BIOL 4321, an undergraduate special topic course at MGA.
ESR1 codes for an estrogen receptor (Chen 2016). Although it only codes for a receptor, there is evidence that prolonged exposure to estrogen increases the chances of breast cancer (Chen 2016). Overexpression of this gene can cause skin and breast cancer (Helman 2014).
Breast cancer is the most common type of cancer besides skin cancer (Chen 2016). An imbalance in cell division and apoptosis leads to excess and uncontrolled growth of cells. These cells also have mutations that allow them to ignore environmental signals to stop growing, and that allow them to infect other areas of the body. |
Sources:
Chen, L., et al. (2016). The association between a novel polymorphism (rs1062577) in ESR1 and breast cancer susceptibility in the Han Chinese women. Gynecological Endocrinology, 32(7), 553.
Helman, E., et al. (2014). Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing. Genome Research, 24(7), 1053.
Chen, L., et al. (2016). The association between a novel polymorphism (rs1062577) in ESR1 and breast cancer susceptibility in the Han Chinese women. Gynecological Endocrinology, 32(7), 553.
Helman, E., et al. (2014). Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing. Genome Research, 24(7), 1053.
Jenna Pollard [email protected] last updated 4/25/2018 www.humangenetics4321.weebly.com